a Record control number WOS:000348529400001

a ISSN 0716-9760

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WP470

b Item number .E97 2014

a Personal name Ozden, Sevgi.

a Title Expression of TRF2 and its prognostic relevance in advanced stage cervical cancer patients

h Medium Electronic Document

c Statement of responsibility, etc Pinar Mega Tiber, Zerrin Ozgen, Hazan Ozyurt, Nedime Serakinci, Oya Orun.

b Name of publisher, distributor, etc Socbıolgıa Chıle,

c Date of publication, distribution, etc 2014.

a Summary, etc Background: Telomeres are protective caps consisted of specific tandem repeats (5 '-TTAGGG-3 '). Shortening of telomeres at each cell division is known as "mitotic clock" of the cells, which renders telomeres as important regulators of lifespan. TRF2 is one of the critical members of shelterin complex, which is a protein complex responsible from the preservation of cap structure, and loss or mutation of TRF2 results in DNA damage, senescence or apoptosis. Since cancer is frequently associated with aberrant cell cycle progression, defective DNA repair or apoptosis pathways, TRF2 could be one likely candidate for cancer therapy.

a Topical term or geographic name as entry element Cervical Cancer

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Main entry heading Bıologıcal Research

g Relationship information Nov 2014, Vol.47 Issue:61

x International Standard Serial Number 07169760

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1186/0717-6287-47-61